Thaum dihydrotanshinone Kuv tua Helicobacter pylori, nws tuaj yeem tsis tsuas yog rhuav tshem biofilm, tab sis tseem tua cov kab mob txuas rau biofilm, uas ua lub luag haujlwm hauv "tshem tawm" Helicobacter pylori.
Bi Hongkai, Xibfwb, Tsev Kawm Ntawv ntawm Cov Tshuaj Yooj Yim, Nanjing Medical University
Cov ntaub ntawv mob qog noj ntshav thoob ntiaj teb tshiab tshaj plaws qhia tias ntawm 4.57 lab tus neeg mob qog noj ntshav tshiab hauv Suav teb txhua xyoo, 480,000 tus neeg mob qog noj ntshav tshiab, suav txog 10.8%, yog nyob rau saum peb. Hauv Suav teb uas muaj tus mob qog noj ntshav siab ntau, tus kab mob sib kis ntawm Helicobacter pylori yog siab li 50%, thiab teeb meem tshuaj tiv thaiv kab mob tiv thaiv kab mob tau zuj zus zuj zus, ua rau muaj kev poob qis hauv kev tshem tawm tas li.
Tsis ntev los no, pab pawg ntawm xibfwb Bi Hongkai, Tsev Kawm Ntawv ntawm Cov Tshuaj Yooj Yim, Nanjing Medical University, tau tshuaj xyuas cov neeg sib tw tshuaj tshiab rau Helicobacter pylori-Dihydrotanshinone I. Dihydrotanshinone Kuv muaj qhov zoo ntawm kev ua haujlwm tau zoo thiab tua tau sai ntawm Helicobacter pylori, tiv thaiv - Helicobacter pylori biofilm, kev nyab xeeb thiab tsis kam tiv taus, thiab lwm yam, thiab cia siab tias yuav nkag mus rau kev tshawb fawb ua ntej ua tus tiv thaiv Helicobacter pylori tus neeg sib tw siv tshuaj. Cov txiaj ntsig tau tshaj tawm online hauv cov ntawv pom zoo thoob ntiaj teb tshuaj tua kab mob "Antimicrobial Agents and Chemotherapy".
Thawj qhov kev kho mob tsis tiav ntawm cov tshuaj ib txwm muaj yog li 10%
Hauv qab lub tshuab tsom iav, qhov ntev tsuas yog 2.5 micrometers rau 4 micrometers, thiab qhov dav tsuas yog 0.5 micrometers rau 1 micrometers. Helicobacter pylori, cov kab mob uas tau muab kauv uas “kis tau cov hniav thiab dhia seev cev”, tuaj yeem tsis tsuas yog ua rau mob hnyav thiab mob ntev, mob plab thiab duodenal thiab lymphatics. Cov kab mob xws li mob qog noj ntshav qog noj ntshav tseem muaj feem cuam tshuam nrog mob qog noj ntshav, mob qog noj ntshav, thiab mob ntshav qab zib.
Kev kho peb npaug thiab plaub npaug uas muaj ob yam tshuaj tua kab mob feem ntau siv hauv kuv lub tebchaws los kho tus mob Helicobacter pylori, tab sis txoj kev kho ib txwm tsis tuaj yeem tshem tawm Helicobacter pylori.
"Qhov ua tsis tiav ntawm thawj qhov kev kho mob ib txwm muaj yog kwv yees li 10%. Qee tus neeg mob yuav muaj mob raws plab lossis mob plab zom mov. Lwm tus ua xua rau penicillin, thiab muaj tshuaj tua kab mob tsawg dua los xaiv. Nyob rau tib lub sijhawm, kev siv tshuaj tua kab mob ntev yuav ua rau cov kab mob Kev txhim kho tshuaj tiv thaiv ua rau cov tshuaj tua kab mob ua haujlwm tsis zoo, thiab cov txiaj ntsig ntawm kev tshem tawm tsis tuaj yeem ua tiav txhua. " Bi Hongkai tau hais tias: "Cov kab mob tiv taus qee yam tshuaj tua kab mob, thiab lawv tseem yuav tiv taus lwm yam tshuaj tua kab mob, thiab kev tiv thaiv kuj tseem tuaj yeem sib txawv. Cov kab mob sib kis mus rau ib leeg dhau los ntawm cov tshuaj tiv taus cov noob, uas ua rau cov tshuaj tiv thaiv kab mob tsis txaus. "
Thaum Helicobacter pylori tawm tsam cov yeeb ncuab ntxeev siab, nws yuav ua kom muaj lub ntsej muag tiv thaiv "biofilm" rau nws tus kheej, thiab biofilm yuav muaj kev tiv thaiv tshuaj tua kab mob, ua rau muaj zog tiv thaiv Helicobacter pylori, cuam tshuam rau kev kho mob thiab txo tus nqi kho.
Salvia miltiorrhiza extract cell kev sim tuaj yeem cuam tshuam ntau hom tshuaj tiv thaiv kab mob
Xyoo 1994, Lub Koom Haum Saib Xyuas Kev Noj Qab Haus Huv (World Health Organization) tau muab cais Helicobacter pylori ua Class I carcinogen vim tias nws ua lub luag haujlwm tseem ceeb hauv kev tshwm sim thiab kev txhim kho mob qog noj ntshav hauv plab. Yuav tshem tawm tus neeg tua neeg noj qab haus huv no li cas? Xyoo 2017, Bi Hongkai pab pawg tau ua dhau los ntawm kev sim ua ntej-Danshen.
Danshen yog ib qho uas tau siv ntau tshaj plaws suav suav tshuaj rau txhawb kev ncig ntshav thiab tshem tawm cov ntshav stasis. Nws cov roj-soluble rho tawm yog tanshinone sib txuas, suav nrog ntau dua 30 monomers xws li tanshinone I, dihydrotanshinone, tanshinone IIA, thiab cryptotanshinone. Tanshinone cov tebchaw muaj ntau yam tshuaj muaj txiaj ntsig zoo, xws li tiv thaiv kabmob kheesxaws, tiv thaiv kabmob zoo, tiv thaiv kabmob, ua haujlwm zoo li cov tshuaj estrogen thiab tiv thaiv kabmob plawv, thiab lwm yam, tabsis cov teebmeem anti-Helicobacter pylori tsis tau tshaj tawm.
"Yav dhau los, peb tau tshuaj xyuas ntau dua 1,000 tshuaj suav tshuaj monomers ntawm qib cell, thiab thaum kawg txiav txim siab tias dihydrotanshinone I monomer hauv Danshen tau muaj txiaj ntsig zoo tshaj plaws hauv kev tua Helicobacter pylori. Thaum ua cov kev sim ntawm tes, peb pom tias thaum lub siab ntawm dihydrotanshinone Kuv tau siv Thaum nws yog 0.125 μg/ml-0.5 μg/ml, nws tuaj yeem tiv thaiv kev loj hlob ntawm ntau hom Helicobacter pylori, suav nrog cov tshuaj tiv thaiv kab mob thiab ntau yam tshuaj tiv taus kab mob . " Bi Hongkai tau hais tias dihydrotanshinone I kuj tseem muaj txiaj ntsig zoo tiv thaiv Helicobacter pylori hauv biofilms. Cov nyhuv tua tau zoo, thiab Helicobacter pylori tsis tsim kev tiv thaiv rau dihydrotanshinone I thaum lub sijhawm dhau mus.
Qhov xav tsis thoob loj yog "Thaum dihydrotanshinone Kuv tua Helicobacter pylori, nws tuaj yeem tsis tsuas yog rhuav tshem biofilm, tab sis tseem tua cov kab mob txuas rau biofilm, uas ua lub luag haujlwm hauv 'rooting' ntawm Helicobacter pylori. "Bi Hongkai tau qhia.
Puas Dihydrotanshinone Kuv tuaj yeem kho Helicobacter pylori?
Txhawm rau ua qhov kev sim ua kom raug ntau dua, Bi Hongkai pab pawg kuj tau tshuaj xyuas cov kev sim hauv nas kom txuas ntxiv txiav txim siab tua cov tshuaj dihydrotanshinone I ntawm Helicobacter pylori.
Bi Hongkai tau tshaj tawm tias hauv kev sim, ob lub lis piam tom qab cov nas tau kis tus kab mob Helicobacter pylori, cov kws tshawb fawb tau faib lawv faib ua 3 pawg, uas yog pab pawg sib koom ua ke ntawm omeprazole thiab dihydrotanshinone I, tus qauv triple regimen administration group, thiab phosphoric acid Hauv pawg tswj tsis tau, cov nas tau muab tshuaj ib hnub ib zaug rau 3 hnub sib law liag.
"Cov txiaj ntsig kev sim qhia pom tias pab pawg sib koom ua ke ntawm omeprazole thiab dihydrotanshinone Kuv muaj qhov ua tau zoo dua hauv kev tua Helicobacter pylori ntau dua li cov qauv pab pawg triple regimen." Bi Hongkai tau hais tias, uas txhais tau tias hauv cov nas, dihydrotanshinone Kuv muaj kev tua neeg ntau dua li cov tshuaj ib txwm muaj.
Thaum twg Dihydrotanshinone Kuv yuav nkag mus hauv tsev ntawm cov neeg zoo tib yam? Bi Hongkai hais ntxiv tias Danshen tsis tuaj yeem siv ncaj qha los tiv thaiv thiab kho tus kab mob Helicobacter pylori, thiab nws cov monomer dihydrotanshinone Kuv tseem nyob deb ntawm kev ua tshuaj uas tuaj yeem siv hauv tsev kho mob. Nws hais tias cov kauj ruam tom ntej yuav txuas ntxiv mus kawm cov txheej txheem ntawm kev txiav txim ntawm dihydrotanshinone I, thiab txhim kho cov tshuaj thiab tshuaj lom ntawm dihydrotanshinone I tiv thaiv Helicobacter pylori. “Txoj kev tom ntej tseem nyob ntev. Kuv vam tias cov tuam txhab tuaj yeem koom nrog hauv kev tshawb fawb ua ntej thiab txuas ntxiv kev tshawb fawb no kom tau txais txiaj ntsig ntau dua cov neeg mob uas muaj kab mob plab. "
Sijhawm Tshaj Tawm: Aug-04-2021